PPP1R9B

Across TCGA patient cohorts, PPP1R9B mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R9B-associated genes across cancer lineages are A-Raf_pS299, MEK1, and TIGAR. Each is linked with PPP1R9B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R9B-to-partner and partner-to-PPP1R9B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PPP1R9B-low versus PPP1R9B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R9B→partner) and Y-score (partner→PPP1R9B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.128	-2.321	.006	.034	3	2
UCEC	MEK1 →	+0.420	+2.584	.003	.010	3	2
UCEC	TIGAR →	+0.143	+3.196	.017	<.001	3	2
UCEC	eEF2 →	+0.454	+3.459	.001	.005	3	1
UCEC	EGFR_pY1068 →	-0.305	-3.169	.001	<.001	3	1
UCEC	eIF4E →	+0.196	+2.115	.018	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

A-Raf_pS299 by PPP1R9B expression — UCEC

Explore this box plot interactively →