PPP1R8

Across TCGA pan-cancer cohorts, PPP1R8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PPP1R8 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPP1R8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R8 expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

HNSC, LUAD, and COAD are the cancer types where PPP1R8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.534	0.912	.001	65	view →
LUAD	DFS	Median	All	0.853	0.626	.001	52	view →
COAD	DFS	Median	III,IV	1.000	0.838	.036	24	view →
PDAC	DFS	Quartile	All	0.906	0.722	.002	11	view →
CCRCC	OS	Median	III,IV	1.000	0.353	.022	3	view →
LSCC	DFS	Quartile	III,IV	0.553	0.984	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PPP1R8–HNSC (DFS)

Open the HNSC breakdown →