PPP1R8

Across TCGA patient cohorts, PPP1R8 mutation is significantly associated with the RNA expression of many other genes, with 719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R8-associated genes across cancer lineages are MIR26A1, RNA5SP411, and RNA5SP419. Each is linked with PPP1R8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R8-to-partner and partner-to-PPP1R8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR26A1 grouped by PPP1R8-low versus PPP1R8-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R8→partner) and Y-score (partner→PPP1R8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR26A1 →	+0.731	+5.306	<.001	.006	3	2
UCEC	RNA5SP411 →	+1.058	+2.171	.001	.009	3	2
UCEC	RNA5SP419 →	+0.836	+2.398	<.001	.007	3	2
UCEC	RNA5SP410 →	+0.617	+2.566	.001	.002	3	2
UCEC	RNA5SP421 →	+0.850	+2.381	<.001	.004	3	2
UCEC	RNA5SP415 →	+0.658	+2.810	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 719 associations by consensus.

MIR26A1 by PPP1R8 expression — CESC

Explore this box plot interactively →