PPP1R8

Across TCGA patient cohorts, PPP1R8 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R8-associated genes across cancer lineages are 14-3-3_beta, JNK_pT183_Y185, and JNK2. Each is linked with PPP1R8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R8-to-partner and partner-to-PPP1R8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PPP1R8-low versus PPP1R8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R8→partner) and Y-score (partner→PPP1R8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.144	-3.143	.004	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.222	-2.308	.008	.036	3	1
UCEC	JNK2 →	+0.265	+2.817	.007	.036	3	1
UCEC	Ku80 →	+0.323	+3.472	.006	.002	3	1
UCEC	Notch1 →	+0.197	+2.321	.005	.035	3	1
UCEC	P-Cadherin →	-0.171	-2.990	.018	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

14-3-3_beta by PPP1R8 expression — UCEC

Explore this box plot interactively →