PPP1R8

Across TCGA cell cohorts, PPP1R8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,377 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPP1R8-associated GO terms across cancer lineages are Negative regulation of chromosome segregation, Spindle elongation, and Mitotic spindle organization. Each is linked with PPP1R8 in more than 15 cancer types. Because this analysis shows association rather than direction, both PPP1R8-to-partner and partner-to-PPP1R8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome segregation grouped by PPP1R8-low versus PPP1R8-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R8→partner) and Y-score (partner→PPP1R8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of chromosome segregation →	+0.111	+0.527	.002	.004	3	16
OESOPHAGUS	Spindle elongation →	+0.210	+0.522	.007	.006	3	15
LIVER	Mitotic spindle organization →	+0.071	+0.609	<.001	<.001	3	15
LIVER	Regulation of metaphase/anaphase transition of cell cycle →	+0.124	+0.657	<.001	<.001	3	15
BREAST	Positive regulation of chromosome condensation →	+0.158	+0.609	<.001	<.001	3	15
BREAST	Mitotic spindle elongation →	+0.215	+0.777	.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,377 associations by consensus.

Negative regulation of chromosome segregation by PPP1R8 expression — LIVER

Explore this box plot interactively →