PPP1R7

Across TCGA pan-cancer cohorts, PPP1R7 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PPP1R7 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PPP1R7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPP1R7 expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRC show a favorable association.

UVM, ACC, and UCS are the cancer types where PPP1R7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.441	0.784	<.001	115	view →
ACC	DFS	Median	All	0.239	0.650	<.001	92	view →
UCS	OS	Tertile	III,IV	0.392	0.764	.007	56	view →
LAML	DFS	Median	All	0.410	0.720	<.001	54	view →
LIHC	OS	Quartile	All	0.537	0.762	<.001	53	view →
SCLC	DFS	Median	III,IV	0.703	0.307	.002	35	view →
HNSC	DFS	Quartile	II,III,IV	0.597	0.855	.003	25	view →
KIRC	DFS	Tertile	All	0.720	0.483	.004	24	view →
LUAD	DFS	Tertile	IV	0.915	0.391	.002	24	view →
THCA	OS	Median	II,III,IV	0.992	0.908	.002	21	view →
KIRP	DFS	Tertile	IV	0.043	0.762	.010	12	view →
DLBC	DFS	Median	All	0.915	0.618	.009	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PPP1R7–UVM (OS)

Open the UVM breakdown →