PPP1R7

Across TCGA pan-cancer cohorts, PPP1R7 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PPP1R7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PPP1R7 RNA is repressed in tumor relative to normal tissue. In most cancer types PPP1R7 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, KIRC, and LIHC are the cancer types where PPP1R7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.348	<.001	11	view →
KIRC	Female	All	+0.482	<.001	11	view →
LIHC	Male	All	+0.783	<.001	9	view →
COAD	All	II,III,IV	+0.206	.002	7	view →
STAD	Male	II,III,IV	+0.429	.006	6	view →
BRCA	All	III,IV	+0.421	<.001	6	view →
CHOL	All	All	+1.354	<.001	5	view →
KIRP	Male	II,III,IV	+0.370	.004	3	view →
LUSC	All	II,III,IV	−0.225	.033	2	view →
BLCA	Male	III,IV	−0.541	.009	1	view →
HNSC	Female	III,IV	−0.268	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PPP1R7–KICH

Open the KICH breakdown →