PPP1R7

Across TCGA pan-cancer cohorts, PPP1R7 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PPP1R7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP1R7 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPP1R7 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and LSCC are the cancer types where PPP1R7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.386	<.001	12	view →
COAD	Male	III,IV	−0.341	<.001	11	view →
LSCC	Female	All	−0.348	<.001	9	view →
CCRCC	Female	All	+0.199	<.001	9	view →
LUAD	All	All	−0.064	.003	6	view →
PDAC	All	III,IV	−0.201	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PPP1R7–HNSC

Open the HNSC breakdown →