PPP1R42

Across TCGA patient cohorts, PPP1R42 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R42-associated genes across cancer lineages are PDCD4, Annexin-1, and S6_pS240_S244. Each is linked with PPP1R42 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R42-to-partner and partner-to-PPP1R42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PPP1R42-low versus PPP1R42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R42→partner) and Y-score (partner→PPP1R42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.710	-3.000	.008	.037	3	1
UCEC	Annexin-1 →	+0.818	+3.000	.007	.037	1	1
UCEC	S6_pS240_S244 →	+0.473	+3.000	.044	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PDCD4 by PPP1R42 expression — UCEC

Explore this box plot interactively →