PPP1R3F

Across TCGA patient cohorts, PPP1R3F mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R3F-associated genes across cancer lineages are GAPDH, ATM, and JNK2. Each is linked with PPP1R3F in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R3F-to-partner and partner-to-PPP1R3F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PPP1R3F-low versus PPP1R3F-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3F→partner) and Y-score (partner→PPP1R3F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.368	+1.700	.048	.042	3	3
UCEC	ATM →	-0.599	-2.893	<.001	.001	3	3
UCEC	JNK2 →	+0.248	+1.736	<.001	.007	3	2
UCEC	MEK1 →	+0.372	+2.459	.003	<.001	3	2
UCEC	Rad50 →	-0.251	-2.070	.002	.001	3	2
UCEC	ASNS →	+0.278	+1.736	.026	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

GAPDH by PPP1R3F expression — UCEC

Explore this box plot interactively →