PPP1R3F

Across TCGA cell cohorts, PPP1R3F mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP1R3F-associated genes across cancer lineages are SIX6, ZIC3, and TLR8. Each is linked with PPP1R3F in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3F-to-partner and partner-to-PPP1R3F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIX6 grouped by PPP1R3F-low versus PPP1R3F-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3F→partner) and Y-score (partner→PPP1R3F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SIX6 →	+2.116	+3.769	<.001	.008	3	2
BLOOD_Leukemia	ZIC3 →	+0.015	+4.060	<.001	.003	3	2
LUNG_NSCLC_LUAD	TLR8 →	+0.030	+4.481	<.001	.001	3	1
LUNG_NSCLC_LUAD	C16orf92 →	+0.048	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	KCNK16 →	+0.027	+4.189	<.001	.002	3	1
UPPER_AERODIGESTIVE_TRACT	WDR87 →	+0.023	+4.209	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

SIX6 by PPP1R3F expression — BLOOD_Leukemia

Explore this box plot interactively →