PPP1R3E

Across TCGA pan-cancer cohorts, PPP1R3E mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PPP1R3E’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PPP1R3E mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPP1R3E is over-expressed in tumor, although a few such as LSCC and HNSC show the opposite, repressed pattern.

LSCC, HNSC, and CCRCC are the cancer types where PPP1R3E tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R3E mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	−0.520	<.001	6	view →
HNSC	All	II,III,IV	−0.369	.043	3	view →
CCRCC	All	All	+0.130	.027	2	view →
LUAD	All	All	−0.175	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PPP1R3E–LSCC

Open the LSCC breakdown →