PPP1R3E

Across TCGA pan-cancer cohorts, PPP1R3E RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PPP1R3E data layer compared with 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PPP1R3E RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R3E expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

UVM, HNSC, and SKCM are the cancer types where PPP1R3E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	0.235	1.000	<.001	65	view →
HNSC	DFS	Quartile	IV	0.722	0.479	.001	61	view →
SKCM	DFS	Quartile	All	0.724	0.554	<.001	51	view →
PAAD	DFS	Tertile	All	0.458	0.163	<.001	43	view →
BRCA	OS	Quartile	III,IV	0.953	0.777	.003	43	view →
UCS	DFS	Median	IV	0.952	0.367	.001	42	view →
COAD	DFS	Quartile	All	0.306	0.603	.001	41	view →
LGG	OS	Median	All	0.871	0.749	<.001	36	view →
KICH	OS	Median	III,IV	0.340	1.000	.001	34	view →
LUSC	OS	Quartile	All	0.837	0.664	<.001	29	view →
LUAD	OS	Quartile	All	0.470	0.281	.003	24	view →
MESO	DFS	Median	IV	0.170	0.499	.005	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PPP1R3E–UVM (DFS)

Open the UVM breakdown →