PPP1R3E

Across TCGA cell cohorts, PPP1R3E mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PPP1R3E-associated genes across cancer lineages are OPRPN, GAGE12D, and GAGE12C. Each is linked with PPP1R3E in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3E-to-partner and partner-to-PPP1R3E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by PPP1R3E-low versus PPP1R3E-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3E→partner) and Y-score (partner→PPP1R3E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OPRPN →	+0.121	+5.029	<.001	.006	3	1
LUNG_SCLC	GAGE12D →	+0.590	+5.643	<.001	.002	3	1
LUNG_SCLC	GAGE12C →	+0.590	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OPRPN by PPP1R3E expression — LUNG_SCLC

Explore this box plot interactively →