PPP1R3D

Across TCGA patient cohorts, PPP1R3D mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R3D-associated genes across cancer lineages are eIF4E, JNK2, and p38-MAPK_pT180_Y182. Each is linked with PPP1R3D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3D-to-partner and partner-to-PPP1R3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PPP1R3D-low versus PPP1R3D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3D→partner) and Y-score (partner→PPP1R3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.211	+2.598	.006	.005	3	2
UCEC	JNK2 →	+0.311	+3.817	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.467	-2.700	.004	.006	3	2
UCEC	PCNA →	+0.209	+1.847	.008	.008	3	2
UCEC	PDCD4 →	-0.485	-1.847	.005	.008	3	2
UCEC	ASNS →	+0.457	+2.700	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

eIF4E by PPP1R3D expression — UCEC

Explore this box plot interactively →