PPP1R3D

Across TCGA pan-cancer cohorts, PPP1R3D RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PPP1R3D data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PPP1R3D RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP1R3D expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, UVM, and HNSC are the cancer types where PPP1R3D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.703	0.489	<.001	135	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	42	view →
HNSC	DFS	Tertile	IV	0.736	0.544	.001	42	view →
CESC	OS	Median	II,III,IV	0.926	0.695	<.001	30	view →
LUSC	OS	Median	II,III,IV	0.705	0.514	.001	28	view →
LGG	DFS	Tertile	All	0.631	0.749	.004	27	view →
MESO	OS	Median	All	0.623	0.464	.016	25	view →
BRCA	DFS	Quartile	All	0.499	0.635	<.001	24	view →
DLBC	DFS	Median	All	0.625	0.916	.011	24	view →
STAD	OS	Median	All	0.630	0.523	.014	23	view →
LUAD	DFS	Median	All	0.511	0.234	.001	18	view →
ACC	OS	Quartile	IV	1.000	0.426	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PPP1R3D–KIRC (DFS)

Open the KIRC breakdown →