PPP1R3D

Across TCGA cell cohorts, PPP1R3D mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R3D-associated genes across cancer lineages are OR10A4, C10orf53, and FAM205A. Each is linked with PPP1R3D in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3D-to-partner and partner-to-PPP1R3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A4 grouped by PPP1R3D-low versus PPP1R3D-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3D→partner) and Y-score (partner→PPP1R3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10A4 →	+0.045	+2.938	.007	.007	3	1
LARGE_INTESTINE	C10orf53 →	+0.010	+3.217	.002	.006	3	1
LARGE_INTESTINE	FAM205A →	+0.018	+3.614	<.001	.006	3	1
LARGE_INTESTINE	TKTL2 →	+0.045	+3.187	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR10A4 by PPP1R3D expression — LARGE_INTESTINE

Explore this box plot interactively →