PPP1R3C

Across TCGA patient cohorts, PPP1R3C mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R3C-associated genes across cancer lineages are ERK2, JNK2, and STAT3_pY705. Each is linked with PPP1R3C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3C-to-partner and partner-to-PPP1R3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PPP1R3C-low versus PPP1R3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3C→partner) and Y-score (partner→PPP1R3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.245	+3.459	.011	.005	3	1
UCEC	JNK2 →	+0.206	+2.834	.039	.034	3	1
UCEC	STAT3_pY705 →	-0.309	-2.999	.019	.035	3	1
UCEC	VHL →	-1.006	-3.000	.003	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-2.308	.019	.036	1	1
UCEC	MEK1 →	+0.445	+3.459	.015	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ERK2 by PPP1R3C expression — UCEC

Explore this box plot interactively →