PPP1R3C

Across TCGA cell cohorts, PPP1R3C mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible PPP1R3C-associated genes across cancer lineages are MBL2 and MMP26. Each is linked with PPP1R3C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3C-to-partner and partner-to-PPP1R3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBL2 grouped by PPP1R3C-low versus PPP1R3C-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3C→partner) and Y-score (partner→PPP1R3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MBL2 →	+0.018	+4.215	<.001	.002	3	1
STOMACH	MMP26 →	+0.673	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

MBL2 by PPP1R3C expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →