PPP1R3B

Across TCGA cell cohorts, PPP1R3B mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R3B-associated genes across cancer lineages are FAM9A, OR2A12, and MUC22. Each is linked with PPP1R3B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3B-to-partner and partner-to-PPP1R3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM9A grouped by PPP1R3B-low versus PPP1R3B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3B→partner) and Y-score (partner→PPP1R3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM9A →	+0.022	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR2A12 →	+0.026	+5.969	<.001	.001	3	1
BLOOD_Leukemia	MUC22 →	+0.006	+6.569	<.001	<.001	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FAM9A by PPP1R3B expression — BLOOD_Leukemia

Explore this box plot interactively →