PPP1R3A

Across TCGA patient cohorts, PPP1R3A mutation is significantly associated with the RNA expression of many other genes, with 7,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R3A-associated genes across cancer lineages are TACC3, DCST1-AS1, and SLC4A2. Each is linked with PPP1R3A in more than 5 cancer types. Because this analysis shows association rather than direction, both PPP1R3A-to-partner and partner-to-PPP1R3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TACC3 grouped by PPP1R3A-low versus PPP1R3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3A→partner) and Y-score (partner→PPP1R3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TACC3 →	+0.497	+1.554	<.001	<.001	3	6
COAD	DCST1-AS1 →	+0.698	+3.335	.001	.005	3	6
LUAD	SLC4A2 →	+0.483	+4.193	<.001	<.001	3	5
UCEC	ZMYND19 →	+0.439	+1.839	<.001	<.001	3	5
UCEC	CDT1 →	+0.788	+1.975	<.001	<.001	3	5
UCEC	FEN1 →	+0.557	+1.468	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,138 associations by consensus.

TACC3 by PPP1R3A expression — UCEC

Explore this box plot interactively →