PPP1R3A

Across TCGA patient cohorts, PPP1R3A mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R3A-associated genes across cancer lineages are ER-alpha, eIF4E, and GSK3-a-b. Each is linked with PPP1R3A in more than 4 cancer types. Because this analysis shows association rather than direction, both PPP1R3A-to-partner and partner-to-PPP1R3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by PPP1R3A-low versus PPP1R3A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3A→partner) and Y-score (partner→PPP1R3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ER-alpha →	-0.166	-2.786	.014	.003	3	4
UCEC	eIF4E →	+0.157	+2.676	.003	<.001	3	4
STAD	GSK3-a-b →	+0.144	+1.606	.026	.041	3	3
COAD	Cyclin-B1 →	+0.921	+3.008	.001	.019	1	5
SKCM	Caveolin-1 →	-0.500	-1.129	.001	.005	3	3
UCEC	ATM →	-0.533	-1.584	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

ER-alpha by PPP1R3A expression — STAD

Explore this box plot interactively →