PPP1R3A

Across TCGA cell cohorts, PPP1R3A RNA expression is significantly associated with the go_rna of many other GO terms, with 101 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PPP1R3A-associated GO terms across cancer lineages are Synaptic transmission, cholinergic, Response to exogenous dsRNA, and Cell motility involved in cerebral cortex radial glia guided migration. Each is linked with PPP1R3A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3A-to-partner and partner-to-PPP1R3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Synaptic transmission, cholinergic grouped by PPP1R3A-low versus PPP1R3A-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3A→partner) and Y-score (partner→PPP1R3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Synaptic transmission, cholinergic →	+0.086	+0.053	<.001	.003	3	2
BLOOD_Lymphoma	Response to exogenous dsRNA →	+0.075	+0.007	.001	.009	2	2
SOFT_TISSUE	Cell motility involved in cerebral cortex radial glia guided migration →	+0.065	+0.038	.004	.008	3	1
SOFT_TISSUE	Apical junction assembly →	+0.079	+0.030	<.001	.006	3	1
SOFT_TISSUE	Positive regulation of DNA metabolic process →	+0.036	+0.029	.009	.009	3	1
LUNG_SCLC	Response to alkaline pH →	+0.152	+0.045	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

Synaptic transmission, cholinergic by PPP1R3A expression — LUNG_SCLC

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