PPP1R35

Across TCGA patient cohorts, PPP1R35 protein abundance is significantly associated with the RNA expression of many other genes, with 3,545 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PPP1R35-associated genes across cancer lineages are AP1S1, DUS4L, and HIBADH. Each is linked with PPP1R35 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R35-to-partner and partner-to-PPP1R35 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP1R35 versus AP1S1 in HNSC, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R35→partner) and Y-score (partner→PPP1R35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AP1S1 →	+1.139	+0.383	.001	<.001	3	3
LSCC	DUS4L →	+0.576	+0.353	.008	<.001	3	2
LSCC	HIBADH →	+0.413	+0.297	.001	<.001	3	2
HNSC	ZNHIT1 →	+0.862	+0.370	.009	.001	3	2
LSCC	ENY2 →	+0.422	+0.261	.002	.002	3	2
LSCC	SYNE1 →	-0.808	-0.266	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,545 associations by consensus.

PPP1R35 vs AP1S1 — HNSC

Explore this scatter interactively →