PPP1R35

Across TCGA cell cohorts, PPP1R35 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,404 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP1R35-associated GO terms across cancer lineages are Pre-mRNA catabolic process, Activation of transmembrane receptor protein tyrosine kinase activity, and Cilium or flagellum-dependent cell motility. Each is linked with PPP1R35 in more than 16 cancer types. Because this analysis shows association rather than direction, both PPP1R35-to-partner and partner-to-PPP1R35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-mRNA catabolic process grouped by PPP1R35-low versus PPP1R35-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R35→partner) and Y-score (partner→PPP1R35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Pre-mRNA catabolic process →	+0.303	+1.578	<.001	<.001	3	17
OVARY	Activation of transmembrane receptor protein tyrosine kinase activity →	+0.368	+0.714	.008	.005	1	12
KIDNEY	Cilium or flagellum-dependent cell motility →	-0.052	-0.484	.001	.008	3	10
KIDNEY	Cilium-dependent cell motility →	-0.052	-0.484	.001	.008	3	10
SKIN	Methylglyoxal catabolic process →	+0.142	+0.841	.001	.002	3	9
OVARY	tRNA dihydrouridine synthesis →	+0.085	+0.585	.001	.008	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,404 associations by consensus.

Pre-mRNA catabolic process by PPP1R35 expression — BONE

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