PPP1R35

Across TCGA cell cohorts, PPP1R35 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP1R35-associated genes across cancer lineages are OR11H1, IQCF5, and MYH4. Each is linked with PPP1R35 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R35-to-partner and partner-to-PPP1R35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H1 grouped by PPP1R35-low versus PPP1R35-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R35→partner) and Y-score (partner→PPP1R35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR11H1 →	+0.063	+5.201	<.001	.006	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MYH4 →	+0.006	+5.969	<.001	.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
BLOOD_Leukemia	FZD10 →	+0.020	+6.149	<.001	.001	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR11H1 by PPP1R35 expression — BLOOD_Leukemia

Explore this box plot interactively →