PPP1R35-AS1

Across TCGA pan-cancer cohorts, PPP1R35-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PPP1R35-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PPP1R35-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PPP1R35-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, LIHC, and COAD are the cancer types where PPP1R35-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R35-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.818	<.001	9	view →
LIHC	All	III,IV	+0.624	<.001	9	view →
COAD	Male	II,III,IV	+0.747	<.001	8	view →
KIRC	All	II,III,IV	−0.301	<.001	6	view →
HNSC	Female	III,IV	−0.608	.002	4	view →
KICH	All	All	−0.459	.007	3	view →
PRAD	All	All	+0.559	<.001	2	view →
LUAD	Female	All	−0.364	.007	2	view →
HNSC	Male	III,IV	+0.325	.030	1	view →
STAD	All	All	+0.229	.034	1	view →
BRCA	Female	All	−0.174	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

PPP1R35-AS1–THCA

Open the THCA breakdown →