PPP1R32

Across TCGA patient cohorts, PPP1R32 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R32-associated genes across cancer lineages are Tuberin_pT1462, JNK2, and MEK1. Each is linked with PPP1R32 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R32-to-partner and partner-to-PPP1R32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by PPP1R32-low versus PPP1R32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R32→partner) and Y-score (partner→PPP1R32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin_pT1462 →	+0.343	+2.594	<.001	.006	3	2
UCEC	JNK2 →	+0.242	+2.331	.006	.019	3	1
UCEC	MEK1 →	+0.482	+3.807	.003	<.001	3	1
UCEC	Akt_pT308 →	+0.763	+2.321	.007	.034	3	1
UCEC	PRAS40_pT246 →	+0.198	+2.013	.010	.018	3	1
UCEC	Caspase-8 →	-0.255	-2.973	.024	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Tuberin_pT1462 by PPP1R32 expression — UCEC

Explore this box plot interactively →