PPP1R2B

Across TCGA patient cohorts, PPP1R2B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R2B-associated genes across cancer lineages are EGFR_pY1068, JNK2, and NF2. Each is linked with PPP1R2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R2B-to-partner and partner-to-PPP1R2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PPP1R2B-low versus PPP1R2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R2B→partner) and Y-score (partner→PPP1R2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.378	-3.000	.009	.036	3	1
UCEC	JNK2 →	+0.415	+3.009	<.001	.019	3	1
UCEC	NF2 →	+0.509	+3.000	<.001	.037	3	1
UCEC	Notch1 →	+0.206	+3.000	.011	.037	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.734	-2.986	.004	.037	3	1
UCEC	Rab11 →	-0.203	-2.980	.015	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by PPP1R2B expression — UCEC

Explore this box plot interactively →