PPP1R2B

Across TCGA cell cohorts, PPP1R2B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,366 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPP1R2B-associated GO terms across cancer lineages are Positive regulation of RNA polymerase II transcription preinitiation complex assembly, Response to hypobaric hypoxia, and Response to dehydroepiandrosterone. Each is linked with PPP1R2B in more than 10 cancer types. Because this analysis shows association rather than direction, both PPP1R2B-to-partner and partner-to-PPP1R2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of RNA polymerase II transcription preinitiation complex assembly grouped by PPP1R2B-low versus PPP1R2B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R2B→partner) and Y-score (partner→PPP1R2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.151	+0.064	<.001	.002	3	11
BONE	Response to hypobaric hypoxia →	+0.142	+0.083	<.001	<.001	3	10
BONE	Response to dehydroepiandrosterone →	+0.199	+0.089	<.001	<.001	3	9
PANCREAS	Regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.126	+0.089	.001	<.001	2	9
BONE	Regulation of protein localization to nucleus →	+0.076	+0.099	<.001	<.001	3	8
SOFT_TISSUE	Negative regulation of protein-containing complex assembly →	+0.084	+0.068	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,366 associations by consensus.

Positive regulation of RNA polymerase II transcription preinitiation complex assembly by PPP1R2B expression — BONE

Explore this box plot interactively →