PPP1R21

Across TCGA patient cohorts, PPP1R21 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,741 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PPP1R21-associated proteins across cancer lineages are HM13, TBCK, and SNRPD2. Each is linked with PPP1R21 in more than 4 cancer types. Because this analysis shows association rather than direction, both PPP1R21-to-partner and partner-to-PPP1R21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP1R21 versus HM13 in UCEC, with a Pearson correlation of -0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R21→partner) and Y-score (partner→PPP1R21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HM13 →	-0.681	-0.512	<.001	.007	3	5
COAD	TBCK →	+0.195	+0.231	.001	.004	3	5
PDAC	SNRPD2 →	+0.177	+0.295	<.001	<.001	3	4
GBM	NAXE →	+0.258	+0.282	.001	.001	3	4
LSCC	SF3A1 →	+0.141	+0.355	<.001	<.001	3	4
LSCC	HNRNPLL →	+0.258	+0.551	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,741 associations by consensus.

PPP1R21 vs HM13 — UCEC

Explore this scatter interactively →