PPP1R21

Across TCGA pan-cancer cohorts, PPP1R21 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated PPP1R21 data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PPP1R21 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PPP1R21 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THCA show a favorable association.

KIRC, THCA, and ACC are the cancer types where PPP1R21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.766	0.502	<.001	141	view →
THCA	DFS	Quartile	All	1.000	0.596	<.001	76	view →
ACC	DFS	Median	All	0.274	0.618	<.001	60	view →
LIHC	OS	Median	All	0.716	0.831	.001	57	view →
SKCM	DFS	Quartile	All	0.705	0.467	<.001	39	view →
BLCA	DFS	Quartile	All	0.166	0.550	.002	39	view →
MESO	DFS	Median	II,III,IV	0.262	0.638	.003	33	view →
DLBC	DFS	Median	All	0.428	0.782	.011	21	view →
LUAD	DFS	Tertile	III,IV	0.709	0.507	.019	18	view →
SCLC	DFS	Tertile	II,III,IV	0.707	0.412	.030	9	view →
LUSC	OS	Tertile	All	0.740	0.621	.009	8	view →
UCEC	DFS	Quartile	All	0.471	0.668	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

PPP1R21–KIRC (OS)

Open the KIRC breakdown →