PPP1R21

Across TCGA patient cohorts, PPP1R21 protein abundance is significantly associated with the RNA expression of many other genes, with 13,344 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PPP1R21-associated genes across cancer lineages are FAM83D, TM6SF1, and KIF23. Each is linked with PPP1R21 in more than 6 cancer types. Because this analysis shows association rather than direction, both PPP1R21-to-partner and partner-to-PPP1R21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPP1R21 versus FAM83D in BRCA, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R21→partner) and Y-score (partner→PPP1R21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM83D →	-1.024	-0.170	<.001	<.001	3	7
BRCA	TM6SF1 →	+0.552	+0.155	<.001	.002	3	7
UCEC	KIF23 →	-1.044	-0.187	<.001	<.001	3	7
BRCA	DIAPH3 →	-0.718	-0.182	<.001	<.001	3	7
OV	CCNA2 →	-1.132	-0.259	<.001	<.001	3	7
GBM	SCN2B →	+1.065	+0.135	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,344 associations by consensus.

PPP1R21 vs FAM83D — BRCA

Explore this scatter interactively →