PPP1R21

Across TCGA patient cohorts, PPP1R21 mutation is significantly associated with the RNA expression of many other genes, with 3,290 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R21-associated genes across cancer lineages are GLRX5P1, NKAPD1, and SRFBP1. Each is linked with PPP1R21 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R21-to-partner and partner-to-PPP1R21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLRX5P1 grouped by PPP1R21-low versus PPP1R21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R21→partner) and Y-score (partner→PPP1R21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLRX5P1 →	+0.271	+1.645	.009	.008	3	3
UCEC	NKAPD1 →	+0.338	+2.332	.006	.003	3	2
UCEC	SRFBP1 →	+0.579	+2.556	<.001	<.001	3	2
UCEC	GUF1 →	+0.450	+2.212	<.001	.001	3	2
UCEC	HAUS1 →	+0.457	+2.032	.003	<.001	3	2
UCEC	BUB3 →	+0.426	+2.490	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,290 associations by consensus.

GLRX5P1 by PPP1R21 expression — UCEC

Explore this box plot interactively →