PPP1R21

Across TCGA patient cohorts, PPP1R21 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R21-associated genes across cancer lineages are PKC-delta_pS664, 14-3-3_beta, and eEF2. Each is linked with PPP1R21 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R21-to-partner and partner-to-PPP1R21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by PPP1R21-low versus PPP1R21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R21→partner) and Y-score (partner→PPP1R21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.110	-3.807	.009	<.001	3	3
UCEC	14-3-3_beta →	-0.106	-2.673	.002	.005	3	2
UCEC	eEF2 →	+0.303	+3.169	.016	.018	3	2
UCEC	EGFR_pY1068 →	-0.306	-3.700	<.001	.001	3	2
UCEC	A-Raf_pS299 →	-0.141	-1.662	<.001	.011	3	2
UCEC	ACVRL1 →	-0.112	-2.887	.020	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PKC-delta_pS664 by PPP1R21 expression — UCEC

Explore this box plot interactively →