PPP1R21

Across TCGA cell cohorts, PPP1R21 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R21-associated genes across cancer lineages are A3GALT2, HTN3, and FGF4. Each is linked with PPP1R21 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R21-to-partner and partner-to-PPP1R21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A3GALT2 grouped by PPP1R21-low versus PPP1R21-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R21→partner) and Y-score (partner→PPP1R21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	A3GALT2 →	+0.022	+4.191	.008	.007	3	1
BLOOD_Lymphoma	HTN3 →	+0.073	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	FGF4 →	+0.022	+5.247	<.001	.001	3	1
BLOOD_Leukemia	DEFA3 →	+3.909	+3.551	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

A3GALT2 by PPP1R21 expression — BLOOD_Lymphoma

Explore this box plot interactively →