PPP1R1B

Across TCGA pan-cancer cohorts, PPP1R1B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PPP1R1B data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPP1R1B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPP1R1B expression acts as an unfavorable survival marker.

UCEC, PRAD, and SKCM are the cancer types where PPP1R1B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
PRAD	DFS	Median	All	0.151	0.888	<.001	6	view →
SKCM	DFS	Median	All	0.225	0.642	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PPP1R1B–UCEC (OS)

Open the UCEC breakdown →