PPP1R1B

Across TCGA pan-cancer cohorts, PPP1R1B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PPP1R1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPP1R1B RNA is repressed in tumor relative to normal tissue. In most cancer types PPP1R1B is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where PPP1R1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−2.828	<.001	12	view →
THCA	Male	III,IV	+3.357	<.001	11	view →
KIRP	Female	All	−1.695	<.001	11	view →
LUSC	Male	II,III,IV	−2.861	<.001	9	view →
BLCA	All	All	−2.238	<.001	9	view →
HNSC	Male	II,III,IV	−2.084	<.001	9	view →
BRCA	All	III,IV	−2.705	<.001	6	view →
STAD	Male	All	+2.900	<.001	5	view →
CHOL	All	II,III,IV	+6.439	.011	4	view →
KICH	All	All	−0.923	.006	3	view →
ESCA	All	All	+3.686	.003	2	view →
LUAD	Male	All	−1.426	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PPP1R1B–KIRC

Open the KIRC breakdown →