PPP1R1B

Across TCGA pan-cancer cohorts, PPP1R1B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPP1R1B data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPP1R1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP1R1B expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

UCEC, COAD, and PDAC are the cancer types where PPP1R1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.958	0.720	.005	28	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.854	.034	18	view →
PDAC	DFS	Quartile	All	0.607	0.300	.008	16	view →
LSCC	DFS	Quartile	All	0.792	0.961	.010	9	view →
HNSC	OS	Quartile	II,III,IV	0.937	1.000	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPP1R1B–UCEC (DFS)

Open the UCEC breakdown →