PPP1R1B

Across TCGA patient cohorts, PPP1R1B mutation is significantly associated with the RNA expression of many other genes, with 618 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R1B-associated genes across cancer lineages are MIR6894, HIGD1AP15, and MIR6069. Each is linked with PPP1R1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R1B-to-partner and partner-to-PPP1R1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6894 grouped by PPP1R1B-low versus PPP1R1B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R1B→partner) and Y-score (partner→PPP1R1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6894 →	+0.488	+4.506	<.001	.009	3	2
SKCM	HIGD1AP15 →	+0.135	+3.490	<.001	.008	3	2
LIHC	MIR6069 →	+0.448	+4.174	.001	.009	3	1
BRCA	OR8S21P →	+0.322	+4.635	.001	.004	3	1
BRCA	MIR6777 →	+0.335	+4.575	.007	.009	3	1
LIHC	MIR4457 →	+1.097	+5.902	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 618 associations by consensus.

MIR6894 by PPP1R1B expression — BRCA

Explore this box plot interactively →