PPP1R1B

Across TCGA patient cohorts, PPP1R1B mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R1B-associated genes across cancer lineages are p70-S6K, Notch1, and p27_pT157. Each is linked with PPP1R1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R1B-to-partner and partner-to-PPP1R1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by PPP1R1B-low versus PPP1R1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R1B→partner) and Y-score (partner→PPP1R1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.200	+2.827	.039	.035	3	2
UCEC	Notch1 →	+0.219	+3.459	.001	.005	3	1
UCEC	p27_pT157 →	+0.064	+2.846	.027	.034	3	1
UCEC	p62 Lck ligand →	+0.354	+3.459	.030	.005	3	1
UCEC	PDCD4 →	-0.561	-3.160	.017	.019	3	1
UCEC	TSC1 →	-0.208	-2.321	.015	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

p70-S6K by PPP1R1B expression — UCEC

Explore this box plot interactively →