PPP1R1A

Across TCGA pan-cancer cohorts, PPP1R1A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPP1R1A data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPP1R1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R1A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where PPP1R1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.395	0.888	<.001	64	view →
HNSC	DFS	Median	All	1.000	0.291	.005	27	view →
LUAD	DFS	Median	All	0.955	0.315	.038	9	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
LSCC	OS	Median	All	0.925	0.699	.029	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPP1R1A–CCRCC (DFS)

Open the CCRCC breakdown →