PPP1R16B

Across TCGA pan-cancer cohorts, PPP1R16B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPP1R16B data layer compared with 22 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPP1R16B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PPP1R16B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where PPP1R16B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.778	0.989	.008	22	view →
CCRCC	DFS	Median	III,IV	0.752	0.310	.006	17	view →
LUAD	DFS	Tertile	II,III,IV	0.684	0.161	.024	7	view →
LSCC	DFS	Tertile	III,IV	0.456	1.000	.019	5	view →
GBM	DFS	Quartile	All	0.292	0.418	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPP1R16B–HNSC (OS)

Open the HNSC breakdown →