PPP1R16B

Across TCGA pan-cancer cohorts, PPP1R16B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PPP1R16B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PPP1R16B RNA is repressed in tumor relative to normal tissue. In most cancer types PPP1R16B is over-expressed in tumor, although a few such as KIRP and COAD show the opposite, repressed pattern.

KIRP, COAD, and THCA are the cancer types where PPP1R16B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R16B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−2.853	<.001	11	view →
COAD	Female	III,IV	−1.646	<.001	11	view →
THCA	Male	III,IV	−1.558	<.001	10	view →
KICH	Female	All	−2.363	<.001	8	view →
LUSC	Male	II,III,IV	−2.202	<.001	8	view →
LUAD	Female	III,IV	−1.592	<.001	8	view →
UCEC	All	All	−2.180	<.001	6	view →
BRCA	All	III,IV	−2.129	<.001	6	view →
BLCA	All	All	−0.856	.004	6	view →
LIHC	Female	II,III,IV	+0.865	.018	3	view →
READ	All	All	−1.292	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PPP1R16B–KIRP

Open the KIRP breakdown →