PPP1R16B

Across TCGA patient cohorts, PPP1R16B mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R16B-associated genes across cancer lineages are ASNS, FOXO3a_pS318_S321, and GAPDH. Each is linked with PPP1R16B in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R16B-to-partner and partner-to-PPP1R16B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PPP1R16B-low versus PPP1R16B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R16B→partner) and Y-score (partner→PPP1R16B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.240	+1.415	.035	.043	3	3
UCEC	FOXO3a_pS318_S321 →	-0.105	-1.504	.007	.014	3	2
COAD	GAPDH →	+0.564	+2.178	.018	.035	3	2
UCEC	ARID1A →	-0.176	-2.051	.002	<.001	3	2
UCEC	TIGAR →	+0.141	+2.142	.003	<.001	3	2
UCEC	ATM →	-0.487	-2.986	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ASNS by PPP1R16B expression — UCEC

Explore this box plot interactively →