PPP1R16B

Across TCGA cell cohorts, PPP1R16B mutation is significantly associated with the RNA expression of many other genes, with 137 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R16B-associated genes across cancer lineages are ZIC5, ACSM2B, and CRYBA1. Each is linked with PPP1R16B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R16B-to-partner and partner-to-PPP1R16B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC5 grouped by PPP1R16B-low versus PPP1R16B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R16B→partner) and Y-score (partner→PPP1R16B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZIC5 →	+0.497	+3.426	.001	.007	3	2
CNS	ACSM2B →	+0.013	+5.321	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	CRYBA1 →	+0.035	+3.722	.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	GPR152 →	+0.113	+3.857	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	HTR3D →	+0.023	+3.870	.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	DUSP29 →	+0.042	+3.870	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 137 associations by consensus.

ZIC5 by PPP1R16B expression — BLOOD_Leukemia

Explore this box plot interactively →