PPP1R16A

Across TCGA pan-cancer cohorts, PPP1R16A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP1R16A data layer compared with 20 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPP1R16A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPP1R16A expression acts as an unfavorable survival marker.

HNSC, SCLC, and UCEC are the cancer types where PPP1R16A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.138	0.751	<.001	48	view →
SCLC	OS	Median	All	0.082	0.708	<.001	36	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPP1R16A–HNSC (OS)

Open the HNSC breakdown →