PPP1R16A

Across TCGA pan-cancer cohorts, PPP1R16A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PPP1R16A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPP1R16A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPP1R16A is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, LIHC, and KIRC are the cancer types where PPP1R16A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R16A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+0.972	<.001	10	view →
LIHC	Male	II,III,IV	+1.967	<.001	9	view →
KIRC	All	III,IV	+0.508	<.001	9	view →
BLCA	All	III,IV	+0.978	<.001	8	view →
LUAD	All	II,III,IV	+0.614	<.001	7	view →
STAD	All	II,III,IV	+0.956	<.001	6	view →
LUSC	All	All	+0.510	<.001	6	view →
KICH	All	All	−0.744	<.001	5	view →
BRCA	All	All	+0.283	.004	4	view →
CHOL	All	All	+1.174	<.001	3	view →
ESCA	All	II,III,IV	+1.864	.006	2	view →
PAAD	All	All	+1.067	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PPP1R16A–COAD

Open the COAD breakdown →