PPP1R15B

Across TCGA cell cohorts, PPP1R15B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,479 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP1R15B-associated GO terms across cancer lineages are Establishment of protein localization to endoplasmic reticulum membrane, Protein modification by small protein removal, and Positive regulation of mRNA metabolic process. Each is linked with PPP1R15B in more than 14 cancer types. Because this analysis shows association rather than direction, both PPP1R15B-to-partner and partner-to-PPP1R15B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to endoplasmic reticulum membrane grouped by PPP1R15B-low versus PPP1R15B-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R15B→partner) and Y-score (partner→PPP1R15B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Establishment of protein localization to endoplasmic reticulum membrane →	+0.109	+0.502	<.001	<.001	3	15
OESOPHAGUS	Protein modification by small protein removal →	+0.049	+0.696	.004	.003	3	13
SOFT_TISSUE	Positive regulation of mRNA metabolic process →	+0.071	+1.106	<.001	<.001	3	11
LARGE_INTESTINE	Intracellular magnesium ion homeostasis →	+0.144	+0.646	<.001	<.001	3	10
BONE	Nuclear pore organization →	+0.151	+0.441	.002	.009	2	11
LUNG_NSCLC_LUSC	Nuclear pore complex assembly →	+0.134	+1.070	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,479 associations by consensus.

Establishment of protein localization to endoplasmic reticulum membrane by PPP1R15B expression — SKIN

Explore this box plot interactively →