PPP1R15B

Across TCGA cell cohorts, PPP1R15B mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PPP1R15B-associated genes across cancer lineages are OR3A3, IL3, and OR51Q1. Each is linked with PPP1R15B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R15B-to-partner and partner-to-PPP1R15B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR3A3 grouped by PPP1R15B-low versus PPP1R15B-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R15B→partner) and Y-score (partner→PPP1R15B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR3A3 →	+0.025	+5.000	<.001	.006	3	1
PANCREAS	IL3 →	+0.023	+5.614	<.001	.002	3	1
PANCREAS	OR51Q1 →	+0.107	+5.000	<.001	.006	3	1
PANCREAS	UBQLN3 →	+0.015	+5.000	.008	.006	3	1
PANCREAS	OR6C2 →	+0.026	+5.000	<.001	.006	3	1
PANCREAS	OR2G6 →	+0.006	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR3A3 by PPP1R15B expression — PANCREAS

Explore this box plot interactively →